HYPERVARIABLE MINISATELLITE REGIONS IN HUMAN DNA PDF

The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.

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In addition to providing confirmatory evidence that minisatellites cluster with other tandem repeats, these flanking sequences contain a high frequency of interspersed repetitive elements. Minisatellites have been implicated [ citation needed ] as regulators of gene expression e. Your comment will be reviewed and published at the journal’s discretion. The first human minisatellite was discovered in by A. This article may be confusing or unclear to readers.

Close mobile search navigation Article navigation. Thank you for submitting a comment on this article. We present our own findings concerning this element, in particular that those examples studied do not show significant evolutionary conservation, despite suggestions that the element may have a cis-acting function.

Minisatellite variant repeat mapping by PCR MVR-PCR has been extensively used to chart the interspersion patterns of variant repeats along the array, which provides details on the structure of the alleles before and after mutation.

This article has multiple issues. Minisatellites are small sequences of DNA that do not encode proteins but appear throughout the genome hundreds of times, with many repeated copies lying next to each other.

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Minisatellites consist of repetitive, generally GC -rich, [ citation needed ] motifs that range in length from 10 to over base pairs. Additional analyses of DNA sequences flanking human minisatellites have also revealed an intense and highly localized meiotic crossover hotspot that is centered upstream of the miniswtellite side of minisatellite arrays. Add comment Close comment form modal.

When shorter 10—bp tandem repeats were later identified, they came to be known as minisatellites. Abstract We present DNA sequences flanking cloned hypervariable human minisatellites. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide.

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Minisatellite – Wikipedia

Please help dba it or discuss these issues on the talk page. This article needs attention from an expert in Genetics. We present DNA sequences flanking cloned hypervariable human minisatellites. Please add a reason or a talk parameter to this template to explain the issue with the article.

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Minisatellite

You do not currently have access to this article. The human telomere sequence itself is a tandem repeat: Dynamic evolution of megasatellites in yeasts. Finally, with the discovery of tandem iterations of simple sequence motifs, the term microsatellites was coined.

Somatic changes are suggested to result from replication difficulties which might include replication slippageamong other phenomena.

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In alternative models, it is the juman of neighbouring double-strand hotspots which is the primary cause of minisatellite repeat dnx number variations.

The name “satellite” refers to the early observation that centrifugation of genomic DNA in a test tube separates a prominent layer of bulk DNA from accompanying “satellite” layers of repetitive DNA. For the size class of orbiting spacecraft, see miniaturized satellite.

You must accept the terms and conditions. Such an event would ultimately lead to the extinction of a hypermutable minisatellite by meiotic drive. Oxford University Press is a department of the University of Oxford. Emery’s Elements of Medical Genetics, 12th. By using this site, you agree to the Terms of Use and Privacy Policy.

Most users should sign in with their email address. I agree to the terms and conditions. Learn how and when to remove these template messages. A minisatellite is a tract of repetitive DNA in which certain DNA motifs ranging in length from 10—60 base pairs are typically repeated times.

Please help us clarify the article. Somatic instability detected in blood DNA shows simple and rare intra-allelic events two to three orders of magnitude lower than in sperm. Sign In Forgot password?

Minisatellites are prominent in the centromeres and telomeres of chromosomes, the minisafellite protecting the chromosomes from damage. This article is also available for rental through DeepDyve.